Friday, February 11, 2011 New in the Literature: Supported Treadmill Training (Arch Phys Med Rehabil. Vol 92 Issue 1) Twelve weeks of body-weight supported treadmill training (BWSTT) produces beneficial effects on quality of life and potentially reduces fatigue in patients with primary progressive multiple sclerosis (MS) of high disability level, say authors of an article published in the January issue (Vol 92, Issue 1) of the Archives of Physical Medicine and Rehabilitation. In a before-after trial study conducted in an exercise rehabilitation research center, patients with progressive MS (N=6; 5 primary progressive, 1 secondary progressive) with high disability (mean±SD expanded disability status scale, [EDSS]=6.9±1.07) completed 36 sessions of BWSTT (30-minute sessions, 3 times a week) over 12 weeks. The main outcome measures included functional ability assessed by EDSS and Multiple Sclerosis Functional Composite (MSFC). Quality of life and fatigue were assessed by the MS Quality of Life-54 (MSQoL-54) and the Modified Fatigue Impact Scale (MFIS), respectively. All tests were administered at baseline and after 12 weeks of training. All participants progressively improved training intensity; treadmill walking speed increased (34%), and percent body weight support was reduced (42%). A significant improvement in both physical and mental subscales of the MSQoL-54 was found. Fatigue was nonsignificantly reduced by 31%. However, a large effect size (ES) was noted (ES=-.93). Functional ability remained stable with nonsignificant improvements in MSFC (ES=.23) and EDSS (ES=-.08) scores. Larger trials will be required to confirm these findings and to evaluate further the effects of BWSTT in progressive MS, the authors add.