Skip to main content

Swiss researchers have reported that repair of trauma-associated cartilage injuries in the knee is feasible and safe using autologous cartilage tissue derived from nasal chondrocytes. In the study, engineered tissue grafts grown from nasal septum biopsy specimens were successfully secured in the damaged joint in 10 symptomatic patients. Over the course of 2 years, the repaired tissue assumed the composition of native cartilage, according to Ivan Martin and colleagues from University Hospital Basel.

Health Technology

In addition, mean clinical scores for symptoms, pain, and activities of daily living gradually improved, the researchers reported.

To assess the feasibility of the procedure, the researchers from 2012 to 2016 enrolled 10 patients who had trauma-induced cartilage lesions located on the femoral condyle or trochlea. The chondrocytes were harvested, then cultured for 2 weeks. The procedure itself was a mini-arthrotomy, during which the area of the defect was debrided to expose the subchondral bone. After being trimmed to fit the defect, the graft was placed with the cell layer facing the subchondral bone and secured by sutures and fibrin glue. Patients were required to immobilize the joint in extension for 2 weeks.

Log in or create a free account to keep reading.


Join APTA to get unlimited access to content.


You Might Also Like...

Feature

Looking Ahead: Increasing Use of Robotic Technologies in Clinical Practice

Aug 1, 2020

Advances in robotics and exoskeletons help patients and offer clinicians additional tools.

Feature

New Technology: Keeping It Ethical, Keeping It Legal

Nov 1, 2019

Advances in health care technology raise legal and ethical issues. Here are some situations you soon may encounter, if you haven't already. How should

Feature

PTs on Rehab's Leading Edge: Regenerative Medicine, Robotics, and Genomics

Apr 1, 2019

Physical therapists are playing key roles in innovative rehabilitation technologies.