The most common diagnoses associated with an opioid prescription are related to musculoskeletal pain. For physical therapists, that means we are likely to encounter patients who are using opioids chronically, or who are at risk of or currently have opioid use disorder. Recognizing this, APTA's ChoosePT campaign emphasizes physical therapy over the use of prescription opioids for the management of painful conditions and health care pathways that include musculoskeletal pain management by a physical therapist may protect patients against initiating opioids.